Designing Effective Transdermal Drug Delivery Patches with Simulation

Bridget Paulus | November 29, 2016

Transdermal drug delivery (TDD) patches continuously deliver drugs into the body for a certain amount of time. However, the skin is designed to keep out foreign substances, like drugs. To create a TDD patch that successfully bypasses this barrier, simulation can be used to study drug release and absorption into the skin. To analyze this process, Veryst Engineering created a TDD patch model with the COMSOL Multiphysics® software and compared the results to experimental data.

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Bridget Cunningham | November 14, 2016

When designing a perforated well to recover oil and gas, choosing the right number of perforations with the appropriate properties is key. Too many holes and you run the risk of equipment failure or injury; too few and you decrease productivity levels. One way to achieve this balance and improve the safety and productivity of the recovery operation is to model fluid flow near the wells. Let’s see how the Application Builder makes this process even more efficient.

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Caty Fairclough | October 19, 2016

In certain food and pharmaceutical industries, different types of dryers are used to dry heat-sensitive products. Vacuum dryers offer one solution for removing water and organic solvents from these sensitive substances. For optimal vacuum dryer design performance, engineers need to balance the dual needs of a rapid drying time and high-quality end products. To achieve this, you can study the vacuum drying process with the COMSOL Multiphysics® software.

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Caty Fairclough | October 10, 2016

Mixers are used for different purposes in many modern industries. If you are looking for an efficient mixer design process, you need a simulation tool that enables you to mix and match different mixer elements. With the COMSOL Multiphysics® software, you can create a mixer geometry that fits your own needs. Today, we’ll discuss modeling a laminar mixing problem with a flat-bottom mixer and two turbulent mixing problems with dished-bottom mixers that utilize the k-epsilon and k-omega turbulence models.

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Ionut Prodan | September 13, 2016

Today, guest blogger and Certified Consultant Ionut Prodan of Boffin Solutions, LLC discusses using a hybrid approach to calculate fracture flux in thin structures. When modeling thin fractures within a 3D porous matrix, you can efficiently describe their pressure field by modeling them as 2D objects via the Fracture Flow interface. Significant fracture flux calculation issues, however, may arise for systems of practical interest, such as hydraulic fractures contained within unconventional reservoirs. See how a hybrid approach overcomes such difficulties.

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Ed Fontes | September 9, 2016

In recent versions of the COMSOL Multiphysics® software, we’ve added several new multiphysics interfaces that include the constituent interfaces as separate physics interfaces, with the couplings predefined in the model tree’s Multiphysics node. This provides you with the best of both worlds, combining the flexibility of the constituent physics interfaces and the user-friendly nature of the predefined multiphysics couplings. The latest version of COMSOL Multiphysics® — version 5.2a — is no exception with the new Reacting Flow multiphysics interface.

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Caty Fairclough | September 6, 2016

Refrigerated trucks must maintain a cool temperature in order to avoid damaging the products that they carry. Optimizing the insulation materials and cooling systems of these vehicles is therefore an important step in their design. To ensure that such components work effectively under open- and closed-door cycles, Air Liquide teamed up with SIMTEC, a COMSOL Certified Consultant, to perform heat transfer and CFD simulations with the COMSOL Multiphysics® software.

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Caty Fairclough | August 26, 2016

Around the world, trash is added to landfills at an increasingly rapid rate. Since these landfills take up large areas of land and can cause environmental issues, researchers are looking for safer, space-saving solutions. One option is to convert traditional anaerobic landfills into aerobic bioreactor landfills. This conversion process needs to be studied further, which could take years experimentally. For faster results, researchers at the University of Western Ontario used the COMSOL Multiphysics® software to efficiently analyze this process.

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Beatrice Carasi | August 22, 2016

The numerical analysis of fluid flow and temperature fields can offer valuable insight in many engineering applications. Efficiency, of course, is important when performing such simulations. Here, we’ll discuss the various formulations for fluid flow equations in the COMSOL Multiphysics® simulation software and when it’s best to use each option, paying particular attention to how this selection influences heat transfer analyses. We will also cover how to set up both natural and forced convection simulations using these formulations.

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Bridget Cunningham | August 16, 2016

Like many crops, the quality of dates is heavily impacted by agronomic practices. In Tunisia, for example, such elements have caused these soft edible fruits to become drier in nature. One approach to improving the quality of these dates is thermal processing, where the key unit of operation is hydration. Combining the power of experimental studies with simulation analyses, a team of researchers sought to optimize the hydration process in order to foster greater efficiency and reliability.

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Bridget Cunningham | July 21, 2016

In any form of treatment, it is always desirable to minimize the level of discomfort that the treatment process causes patients, while ensuring overall safety and effectiveness. For diabetes patients, insulin injections remain an important form of treatment, but the process itself can be painful. With the help of multiphysics simulation, a team of researchers from the University of Ontario Institute of Technology sought to develop a MEMS-based micropump that could administer insulin injections in a safe and painless way.

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