Design and Simulation of MEMS Micro Heater for DNA Amplification

D. Sharma [1], A. Siddiqua [1],
[1] Nitte Meenakshi Institute of Technology, Bengaluru, Karnataka, India
Published in 2015

PCR (Polymerase Chain Reaction) is a recent well researched technique which can be employed to obtain an amplified DNA (Deoxyribonucleic Acid). A continuous flow polymerase chain reaction with integrated MEMS based design micro heater for DNA amplification is implemented. Temperature zone is obtained by natural heat conduction rather than making use of typical silicon thermal cycler. Inter connect based upon LTCC or PDMS can be employed for integration. The authors of this paper will be looking in detail about the design implementation of the two way heater, and also will be looking into details about the temperature variation obtained while using two different types of sample (saliva and blood) for DNA amplification. The simulations were carried out using COMSOL Multiphysics software.