D. Barac , Z. Karimadini , R. Croce , D. Iber 
 Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Basel, Switzerland
One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties and functionalities arise from the molecular regulatory networks and how do they evolve? A deeper understanding of morphogenesis and organogenesis in particular is required to advance tissue engineering. Recent advancements in 3D ...
F. Lai , N. K. Shivaprakash , J. Zhang , A. Panwar , J. Mead , C. Barry , Q. Truong ,
 University of Massachusetts Lowell, Lowell, MA, USA
 US Army Natick Soldier Research, Development and Engineering Center, Natick, MA, USA
Micro hot embossing on a large area polymeric substrates using roll-to-roll (R2R) mode has been considered as one of the most promising technologies that can offer continuous fabrication of large area polymeric substrates. Besides continuous operation, roll-to-roll (R2R) process offers advantages such as low forming load and higher replication accuracy. Consequently, R2R embossed polymeric ...
S. Ali, and M. McShane
Department of Biomedical Engineering, Texas A&M University-College Station, Texas, USA
With the rising predominance of diabetes, successful management of blood glucose levels is increasingly important. Key efforts have focused on the development of optical microscale glucose sensing systems based on the encapsulation of glucose oxidase within microspheres coated with polyelectrolyte multilayer nanofilms. A two-substrate mathematical model of microscale optical glucose sensors in ...
B. Jordan, and P. Müller
The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...
Evaluation of Performance of Enzymatic Biofuel Cells with Microelectrode Arrays Inside a Blood Artery via Finite Element Approach
C. Wang, Y. Song
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are considered as a promising candidate for powering miniature implantable devices. In order to predict the performance in the human blood artery, we simulated a 3D EBFC chip with highly dense micro-electrode arrays. In this simulation using COMSOL Multiphysics®, we applied the 1) Michaelis Menten equation; 2) Nernst potential equation; 3) Navier Strokes velocity, ...
A. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...
P. Lezuo, M. Stoddart, and M. Alini
AO Research Institute, Davos, Grison, Switzerland
We aim to develop an in vitro culture system to mimic the human bone marrow stem cell niche in an artificial perfusion bioreactor environment to culture human adult stem cells. State of the art human bone marrow stem cell research shows that even smallest changes in the physical, thermo dynamical or biochemical environment induce a differentiation of human bone marrow stem cells into other cell ...
V. Valente, A. Demosthenous, and R. Bayford
Department of Electronic & Electrical Engineering, University College London, London, United Kingdom
Department of Natural Sciences, Middlesex University, London, United Kingdom
Deep Brain Stimulation (DBS) is a therapeutic tool used for a number of neurological disorders including chronic pain, incontinence and movement disorders, such as Parkinson’s disease. DBS consists of the low-frequency stimulation of an area of the brain, known as basal ganglia. The stimulation is provided by clinical implant, consisting of a pulse generator and an electrode lead ...
D. Gasperino 
 Intellectual Ventures Laboratory, Bellevue, WA, USA
Worldwide, the leading cause of mortality in children is acute respiratory infection, primarily associated with pneumonia. One of the essential tools used to treat life-threatening hypoxemia due to pneumonia is the appropriate use of supplemental oxygen. While oxygen therapy is essential for many aspects of case management in hospitals and large clinics, many such health facilities have no ...