See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.
View the COMSOL Conference 2018 Collection
Bioscience and Bioengineeringx

Homogenized models of electrically-coupled excitable tissues

P. Goel


Pranay Goel received his B. Tech. in Engineering Physics from IIT Bombay, and MS and PhD in Physics from the University of Pittsburgh in 2003. He went on to two postodoctoral positions, the first at the Mathematical Biosciences Institute, The Ohio State University, and another at the ... Read More

A Microfluidic Platform for Electrochemical Concentration and Detection

C. F. Ivory [1], D. E. Molina [1],
[1] Washington State University, Pullman, WA, USA

A poly(methyl methacrylate) (PMMA) microfluidic platform with a hot-embossed microchannel, 150 mm wide and 20 mm deep, was developed for multiple purpose detection using electrochemical methods. This device is able to accommodate a three-electrode system encased in 1/16" diameter PEEK ... Read More

Toward Nano-Scale Scanning Electrochemical Microscopy of Single Live Cells by Means of the COMSOL Multiphysics® software

Z. Ding [1], F. P. Filice [1], M. S. M. Li [1],
[1] Department of Chemistry, University of Western Ontario, London, ON, Canada

Scanning Electrochemical Microscopy (SECM) is a powerful noninvasive analytical technique employed in a variety of applications ranging from electrochemical characterization of material surfaces, to bioanalytical characterization of single live cells [1]. When applied to live cells, SECM ... Read More

Stochastic Modeling of Biological Systems – Ranking the Model Parameters of the Human Vocal Folds

D. Cook[1]
[1]New York University, New York, USA

Computational models of biological systems are becoming more and more common in medical research areas. Evidence of this can be found by examining the number of articles containing the term “finite element” in the expansive National Institutes of Health (NIH) digital research ... Read More

A Virtual Pharmacokinetic Model Of A Human Eye

L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland

Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, ... Read More

Finite Element Analysis Approach for Optimization of Enzyme Activity for Enzymatic Bio-fuel Cell

Y. Song, and C. Wang
Florida International University, Miami, FL, USA

Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode ... Read More

Computational Biophysics in COMSOL®: FSI-Simulations of Cells in a Microfluidic Device

L. D. Wittwer [1], S. Aland [2],
[1] HTW Dresden / TU Dresden, Germany
[2] HTW Dresden, Germany

INTRODUCTION The mechanical properties of biological cells are promising biomarkers to differentiate for example cell phenotypes, cell states or between healthy and unhealthy cells with applications ranging from research facilities to medical laboratories [1, 2]. Real-time ... Read More

Validation of Measurement Strategies and Anisotropic Models Used in Electrical Reconstructions

R. Sadleir
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA

We are developing approximations of electrically anisotropic materials for use in novel imaging methods. Our modeling work in COMSOL comprises comparisons of anisotropic and layered models in terms of electrical conductivities measured using different strategies. We tested solution ... Read More

Numerical Investigation of a Time-dependent Magnetic Actuation Technique for Tagging Biomolecules with Magnetic Nanoparticles in a Microfluidic System

A. Munir, J. Wang, Z. Zhu, and H.S. Zhou
Worcester Polytechnic Institute, Worcester, MA, USA

The magnetic body forces that act on mono-dispersed magnetic nanoparticles (MNPs) tagged biomolecules in a microfluidic system can be efficiently used in various applications that involve separation and detection including DNA and protein analysis, bio-defense, drug delivery, and ... Read More

Using Simulations to Evaluate the Proper Conditions of the in Vitro Culture of Bone Tissue

A. Kahlig[1], J. Hansmann[1], H. Walles[2], and T. Hirth[1]
[1]University Stuttgart, Institute for Interfacial Engineering, Stuttgart, Germany
[2]Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany

For the development of bioreactor systems, it is reasonable to develop working simulations, to avoid a lot \"trial-and-error\" experiments. Our research goal is the creation of functioning bone grafts for transplantation. Therefore stem cells get homogenously seeded into porous ceramic ... Read More