S. D. Evans, J. S. Roth, M. R. Cheetham
University of Leeds, Leeds, UK
Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...
A. Sun, and S. Murray
Dept. of Biomedical Engineering
UCLA, Los Angeles, CA
Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type. We use COMSOL Multiphysics ...
A. González-Suárez, M. Trujillo, J. Koruth, A. D'Avila, E. Berjano
Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA
Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...
Electrical Response and Thermal Damage Assessment of Cutaneous and Subcutaneous Tissues to Noninvasive Radiofrequency Heating: A Computational Modeling Study
A. González-Suárez[1,2], J. N. Jimenez-Lozano, W. Franco
Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA
Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València, Valencia, Spain
ZELTIQ Aesthetics, Inc., Pleasanton, CA, USA
Electromagnetic radiofrequency (RF) sources are widely used to heat up cutaneous and subcutaneous tissues. The subcutaneous morphology of tissue consists of a fine, collagenous and fibrous septa network enveloping clusters of adipocyte cells; however, it is commonly regarded as a homogeneous fat layer in computational models. In the present study the objective is to assess the effect of the ...
I.M. Abdel-Motaleb, J. Lavrencik 
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
There is urgent need to monitor dental and oral diseases, such as tooth decay, gum diseases, and teeth grinding. Such monitoring can be achieved by embedding sensors in the mouth. This technique faces some difficulties. The first is how the power needed for the operation of the sensors and the associated electronic chips can be generated. This power can be generated using the pressure exerted by ...
R. Penjweini , T. C. Zhu , M. M. Kim ,
 Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Photofrin-mediated photodynamic therapy (PDT) is used after surgical resection at the University of Pennsylvania to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rate. When Photofrin is exposed to laser light at 630 nm in well-oxygenated tissue, it produces reacted singlet oxygen ([1O2]rx) that kills cancer cells. As [1O2]rx is imperative to PDT ...
J.J. Dubowski, and D.Carrier
Department of Electrical and Computer Engineering, Université de Sherbrooke, Quebec, Canada
We present a Finite Element Method simulation procedure that allows rapid development of prototype devices comprising novel self-referenced interference SPR (surface plasmon resonance) biosensing microstructures. The procedure takes advantage of COMSOL Multiphysics and MATLAB software and their bi-directional link. The simulation is made using COMSOL RF Module, 2D harmonic propagation ...
Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis
F.J. del Campo, A. Torrents, J. Mas, F.X. Muñoz
Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...
Downscale Finite Element Modeling of Aortic Valve Leaflets for In-Situ Estimation of Cell Level Mechanics
R. Buchanan, M. Sacks
Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas, Austin, TX, USA
As in all tissues, mechanical forces in the aortic valve (AV) modulate the constituent cell population’s physiology and biosynthetic activity. While advances have been made toward the understanding of this complex multi-scale relationship, the specific role that and extracellular matrix (ECM) coupling plays on the mechanical response of the AV interstitial cell (AVIC) is poorly understood. The ...
B. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...